RNA Interference Targeting Connective Tissue Growth Factor Inhibits the Transforming Growth Factor-β2Induced Proliferation in Human Tenon Capsule Fibroblasts

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RNA Interference Targeting Connective Tissue Growth Factor Inhibits the Transforming Growth Factor-β2 Induced Proliferation in Human Tenon Capsule Fibroblasts

Purpose. This study was to determine the effect of CTGF-small interfering RNA (siRNA) on TGF- β 2-induced proliferation in human Tenon capsule fibroblasts (HTFs). Methods. HTFs were transfected with four of CTGF-siRNAs separately for screening of gene silencing efficacy that was determined by transcript level measured by quantitative real-time PCR (qRT-PCR). Recombinant TGF- β 2 was added into ...

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ژورنال

عنوان ژورنال: Journal of Ophthalmology

سال: 2013

ISSN: 2090-004X,2090-0058

DOI: 10.1155/2013/354798